MAF-Test®

MAF-Test^® employs high quality, reliable and easy-to-use DNA probes for fluorescence in situ hybridization (FISH) for the determination of MAF gene amplification in early breast cancer tumors.

MAF-Test^®

The MAF (16q23) / D16Z3 FISH probe (MAF-Test^®) is intended for use in a non-automated semi-qualitative fluorescence in situ hybridization assay to detect amplification involving the MAF gene region at 16q23 in a dual-color assay on formalin fixed paraffin embedded breast cancer tissue sections. The centromere 16 specific centromere repeat probe (D16Z3) is included as control on hybridization efficiency.

• Product Information Sheet

The MAF (16q23) gene region FISH probe is direct-labeled with PlatinumBright™550 (red). The D16Z3 control FISH probe is direct-labeled with PlatinumBright495 (green).

Clinical utility:

MAF gene amplification in primary tumors has been associated with an increased risk of relapse, death, and metastasis, especially bone metastasis, in early-stage breast cancer patients (Paterson et al., 2021). MAF gene amplification may be considered as an adverse prognostic factor of the disease.

Increrased risk of bone and non-bone metastasis in MAF positive patients translates to reduced disease free and overall survival.